Coenzyme Q10: Important Research Studies
Coenzyme Q10 is a fat-soluble vitamin-like substance. It is not classified as a vitamin because the human body naturally produces Coenzyme Q10. Unfortunately, the bio-synthesis [...]
Coenzyme Q10 Absorption and Bioavailability
Coenzyme Q10 health benefits depend on the absorption and bioavailability of the supplement. The producer’s use of carrier oils and heating/cooling process are important for the CoQ10 absorption and bioavailability. It is important to buy a supplement with documented absorption.
What Causes Coenzyme Q10 Deficiency
Coenzyme Q10 plays a central role in cell metabolism. Consequently, CoQ10 deficiency is associated with a wide range of disorders. Supplementation with CoQ10 or with CoQ10 combined with selenium reduces mortality by nearly 50% in patients with heart failure and senior citizens.
Coenzyme Q10 Deficiency Conditions
Normal healthy adults have a CoQ10 status of about 1 mg/L of blood plasma. Heart failure patients benefit from treatment with CoQ10 to raise the plasma level to at least 2.5 mg/L. Aging, mutation in genes, oxidative stress, and statins can all affect the bio-synthesis of CoQ10.
Absorption of Coenzyme Q10 at Body Temperature
CoQ10’s melting point is about 118 degrees Fahrenheit, much higher than body temperature. Below 118 degrees, CoQ10 clumps together into crystals. We cannot absorb CoQ10 crystals; we can only absorb single molecules. For absorption, the CoQ10 supplement formulation is important.
Still Unresolved Coenzyme Q10 Research Issues
The International Coenzyme Q10 Association (the ICQA) is a nonprofit association. The ICQA has existed since 1997. It promotes biochemical and clinical research into the [...]
Large Variation in the Quality of CoQ10 Supplements
Commercially available CoQ10 supplements are quite different from one another in quality and potency. Even if the manufacturers start with the same CoQ10 raw material, the end result can vary considerably.
CoQ10 Absorption Antagonists
The 2019 Lopez-Lluch bioavailability study – the “gold standard” reference for CoQ10 bioavailability studies – showed, among other things, that there is considerable variability [...]
CoQ10 Absorption and Bioavailability
Coenzyme Q10 is not equally well absorbed from all supplements. Some commercially available CoQ10 supplements give a better absorption; some give very little absorption. [...]
The Instability of Ubiquinol – Misleading Marketing Claims?
On the Web, I see many incorrect and undocumented marketing claims for ubiquinol supplements. As a long-time Coenzyme Q10 researcher, I worry that consumers will [...]