Infertility affects 15% of couples (50 million couples) worldwide. Female reproductive potential declines with increasing age – from middle 30s to early 40s. The decline is associated with mitochondrial dysfunction and oxidative stress. Coenzyme Q10 can alleviate these problems.
Elderly individuals who have low Coenzyme Q10 and selenium status are at risk of cognitive decline. In the KiSel-10 Study, daily supplementation with a combination selenium and CoQ10 supplements slowed the aging process. The joint supplementation can improve cognitive function.
Coenzyme Q10 supplements in the ubiquinone form have a proven track record in clinical studies of heart disease. The ubiquinone form increases survival and reduces symptoms in heart failure. It reduces the risk of cardiovascular death. There is no similar evidence for ubiquinol.
Coenzyme Q10 supplementation in the ubiquinone form has well-documented heart health benefits. A recent research review shows that ubiquinone may have similar beneficial effects as an adjunctive therapy in patients with chronic fatigue syndrome, fibromyalgia, and long Covid.
Mitochondria are the tiny bean-shaped micro-organs in our cells. They take the glucose from our food and convert it into ATP energy molecules. Coenzyme Q10 is an essential component in this process of ATP energy generation.
Good liver function becomes increasingly important as we get older. Daily CoQ10 supplements can reduce the serum levels of the ALT, AST, and GGT liver enzymes. Research shows Coenzyme Q10 in 100-400 mg doses seems to protect liver cells and to affect liver function positively.
Ubiquinol is not better than ubiquinone for good heart health. A review of 28 clinical studies shows that ubiquinone is the form of Coenzyme Q10 with documented heart benefits: decreased mortality, reduced hospital time, improved heart function. Ubiquinone is the proven choice.
Supplementation with Coenzyme Q10 increases plasma and leg muscle tissue CoQ10 levels, improves exercise performance and exercise recovery, and does not adversely affect the body’s own synthesis of Coenzyme Q10. CoQ10 is associated with lower levels of muscle and kidney damage.
Adding CoQ10 supplementation to conventional medication for heart failure is very likely to have a positive effect on survival, on quality of life, on the risk of hospitalization, on physical function, and on the cost-effectiveness of treatment according to a recent analysis.
Normal healthy adults have a CoQ10 status of about 1 mg/L of blood plasma. Heart failure patients benefit from treatment with CoQ10 to raise the plasma level to at least 2.5 mg/L. Aging, mutation in genes, oxidative stress, and statins can all affect the bio-synthesis of CoQ10.
